Histomorphometric analysis of microcrack healing after the installation of mini-implants
Shin Soo-Bin, Park Pan-Soo, 백승학, 양일형,
소속 상세정보
( Shin Soo-Bin ) - Seoul National University School of Dentistry Department of Orthodontics
( Park Pan-Soo ) - Seoul National University School of Dentistry Department of Orthodontics
백승학 ( Baek Seung-Hak ) - Seoul National University School of Dentistry Department of Orthodontics
양일형 ( Yang Il-Hyung ) - Seoul National University School of Dentistry Department of Orthodontics
KMID : 0363020150450020062
Abstract
Purpose: The goal of this study was to investigate the histomorphometric characteristics of the healing process of microcracks in the cortical bone after the installation of mini-implants (MIs).
Methods: Self-drilling MIs were inserted into the tibial diaphysis of twelve adult male New Zealand rabbits. Four MIs per rabbit were placed randomly. The animals were divided into four groups according to the length of the healing period: group A was sacrificed immediately, group B was sacrificed after one week, group C was sacrificed after two weeks, and group D was sacrificed after four weeks. Cortical bone thickness was measured using micro-computed tomography, and histomorphometric analyses of the cumulative length of the microcracks (CLCr) and the total number of microcracks (NCr) were performed using hematoxylin and eosin staining.
Results: The microcracks were radially and concentrically aligned in the peri-MI bone. The CLCr decreased significantly one week after the surgery, mainly due to healing of the concentrically aligned microcracks. The CLCr showed another significant decrease from two weeks after the surgery to four weeks after the surgery, mainly reflecting healing of the radially aligned microcracks. A statistically significant decrease in the NCr occurred as the microcracks healed from zero weeks to two weeks. However, no significant difference in the NCr was found between groups C and D.
Conclusions: In order to improve the primary stability of MIs, delayed loading and a healing period of a certain length are recommended to ensure the optimal healing of microcracks and bone remodeling.
키워드
Bone remodeling ; Orthodontic anchorage procedures
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